Reference
參考資料 |
Pathology/Product used
病理症狀/使用產品 |
Key results on performance & adverse events
主要治療結果 & 不良反應記錄 |
| The use of cellular matrix in symptomatic knee osteoarthritis
Abbassy et al
Bosn J of Basic Med Sci 2020
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knee OA(grade II-III)
Cellular Matrix
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- All but one patient reported improvement in pain, stiffness and function at 6 months compared to baseline. The improvement in WOMAC score was statistically significant.
- 68% of patients showed a >50% improvement in pain, stiffness and function.
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| Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial
Lin et al.,
Arthroscopy 2019
|
Knee OA stage I-III
RegenKit THT-1
|
- All groups showed improvement in WOMAC and IKDC scores at 1 month, but this was only sustained in the PRP group at 12 months.
- A significant difference in WOMAC and IKDC scores between the PRP and saline group was seen at 2, 6 and 12 months.
- There was no significant difference in functional outcomes between the HA and saline groups.
- Only the PRP group obtained clinically significant functional improvement at all time points in the WOMAC score and at 6 months in the IKDC score.
- Transient localized pain at he injection site that resolved within a few hours.
|
| An exploratory comparison of single intra-articular injection of platelet-rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee
Li et al
Haemophilia 2019
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Haemophilic arthropathy of knee joints
RegenKit THT-1
|
- In the PRP group, a significant reduction in pain from hemophilic arthropathy of knee was observed for 6 months (F = 17.47, p < 0.01).
- WOMAC score was significantly improved for 6 months after injection (F = 4.78, P < 0.01).
- Significant improvement in synovial hyperemia was also achieved (F = 4.16, p < 0.01).
- The comparative analysis of the two treatments showed no significant intergroup difference.
- PRP injections showed longer efficacy than HA injections in reducing pain and improving knee function.
- No severe adverse events or injection hemarthroses were reported.
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| Nonoperative choice of anterior cruciate ligament partial tear: ultrasound-guided platelet-rich plasma injection
You et al
J Med Ultrasound 2019
|
Anterior cruciate ligament partial tear
RegenKit THT-1
|
- At the 6-month follow-up, the patient reported less pain and improved stability when walking.
- MRI evaluation showed decreased enhancements of the ACL tear in the tibial plateau area and its main trunk.
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| A novel treatment of knee degenerative disorders all- in-one intra-articular injection of platelet-rich plasma combined with hyaluronic acid
Adam et al
Int J Clin Rheumatol 2018
|
Meniscal lesions,Bone marrow edema
Cellular Matrix
|
- Significant improvement in the IKDC score (79.6/100 at 1-year vs. 42/100 before treatment) was observed for patients with meniscal tears. At 2 years, 52% of subjects exhibited long-term improvement.
- Patients with meniscal suture presented no failure at the one-year follow-up.
- The success rate for patients treated for meniscal cysts was 70%.
- No adverse events reported.
|
| The influence of platelet rich plasma on synovial fluid volumes, protein concentrations, and severity of pain in patients with knee osteoarthritis
Chen et al.
Exp Gerontol 2017
|
knee OA(grade II-III) with supra-patellar Bursitis (caused by Accumulation of synovial fluid)
RegenKit THT-1
|
- Knee pain was evaluated with the Lequesne Functional Index, decreasing from 12.21 ± 2.44 to 4.33 ± 0.78 at final follow-up.
- Significant decreases in volume and concentration of SF protein was observed after the completion of the second PRP injection (p<0.05).
- Proteins associated with inflammation decreased at least 2-fold in concentration.
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| PRP injection for the painful hips: the Taiwan series
Pan et al.
Healthy Aging Research 2015
(Poster and abstract)
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Painful advanced hip arthropathies
RegenKit THT-1
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- The successful rate of PRP (pain improvement >50%) is about 70%.
- No severe adverse events were reported. Pain syndrome post injections were reported in less than half of patients.
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