Reference
參考資料 |
Pathology/Product used
病理症狀/使用產品 |
Key results on performance & adverse events
主要治療結果 & 不良反應記錄 |
| A pilot study: effectiveness of local injection of autologous platelet‑rich plasma in treating women with stress urinary Incontinence
Long et al
Scientific Report 2021
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Stress urinary incontinence
RegenKit
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- A-PRP is effective in relieving SUI symptoms at both 1 month and 6 months post-treatment without significant adverse reactions reported. Overall efficacy was 60% (12/20).
- No significant changes in sexual function before and after the treatment were reported by the patients.
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| Efficacy of injecting platelet concentrate combined with hyaluronic acid for the treatment of vulvovaginal atrophy in postmenopausal women with history of breast cancer: a phase 2 pilot study
Hersant et al
Menopause 2018
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Vulvo-vaginal atrophy (VVA)
Cellular Matrix
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- The vaginal health index score increased significantly from baseline and 1-month post treatment and continued to increase at 3 and 6 months.
- Functional results (volume of vaginal secretions, elasticity and epithelial integrity, moisture rate and vaginal pH) improved significantly after treatment.
- The quality of life of patients improved significantly after treatment to reach 17% of improvement at 6 months (FSD score).
- 19/20 patients were satisfied by the treatment (VAS score).
- The injection of PRP-HA appeared to be a promising method to improve the trophicity and hydration of vaginal mucosa for the treatment of VVA in postmenopausal breast cancer survivors with contraindications to hormone therapy.
- No adverse events were observed or reported by the participants.
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| First data on in vitro fertilization and blastocyst formation after intra-ovarian injection of calcium gluconate-activated Autologous platelet rich plasma
Sills et al
Gynecological Endocrinology 2018
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Infertility treatment (blastocyst formation)
RegenKit
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- Increase in AMH hormone after treatment (no significant) and decrease in FSH (p<0.01), sufficient to permit retrieval MIl oocytes.
- IVF occurred, and all patient had at least one blastocyst suitable for conservation.
- Evidence of improved ovarian function was noted in all who received intraovarian PRP, possibly as early as two months after treatment. Additional research is needed to clarify (and enhance) which PRP components are possible for altered ovarian function, and to identify predictive characteristics for patients most likely to benefit from this intervention.
- No serious AE was reported, only mild pain.
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| An innovative approach to treating vaginal mesh exposure after abdominal sacral colpopexy: endoscopic resection of mesh and platelet-rich plasma; initial experience in three women
Castellani et al
Int Urogynecol 2017
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Vaginal vault mesh exposure after laparoscopic ASC with concomitant Hysterectomy
RegenKit
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- 30 days post-PRP injections, physical urogynecological and vaginoscopy examinations showed tissue response to the treatment. Full recovery was already obtained 6-months post injections.
- All women recovered sexual function, and none experienced relapsed pelvic organ prolapse at 1- year follow-up.
- Bipolar plasmakinetic resection (BPR) combined with PRP is an effective technique for treating vaginal mesh exposure with conservation of anatomical results and sexual function.
- PRP represents an alternative method to suture stitches, being decisive in solving problems of responsiveness in hysterectomy surgeries.
- No complications were observed during surgery. 2 patients complained of mild vaginal itching that lasted for 1 month.
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| A pilot study of the effect of localized injections of autologous platelet rich plasma (PRP) for the treatment of female sexual dysfunction
Runels et al
J Women's Health Care 2014
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Female sexual dysfunction (dyspareunia) |
- Clinical findings from FSDS-R and FSFI patient's questionnaires suggested a trend of improvement after injection. 71% of patients improved from "distressed" to "not distressed", with positive changes in sexual-related dysfunctions (desire, arousal, lubrification, orgasm).
- Improvement in satisfaction and pain were noted but were not statistically significant.
- The preliminary results of this pilot study suggest that specifically placed intravaginal and intraclitoral PRP injections could be an effective method to treat certain types of female sexual dysfunction, especially in the areas of desire, arousal, lubrication and orgasm.
- No serious AE reported. Side effects were observed in 2 patients and including sexual arousal with urination and continuous sexual arousal, ejaculatory orgasm, and spontaneous orgasm. Except for ejaculation, these responses only lasted 1 to 2 weeks. All side effects solved spontaneously.
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